翻訳と辞書
Words near each other
・ Fox Theatre (San Francisco, California)
・ Fox Theatre (St. Louis)
・ Fox Theatre (Toronto)
・ Fox Theatre (Visalia, California)
・ Fox Theatre Historic District
・ Fox Theatre Inglewood
・ Fox Theatres
・ Fox toolkit
・ Fox Tor
・ Fox tossing
・ Fox Point, Nova Scotia
・ Fox Point, Providence, Rhode Island
・ Fox Point, Wisconsin
・ Fox Pop
・ Fox Primary School
FOX proteins
・ Fox Racing
・ Fox Racing Shox
・ Fox Radio
・ Fox Range
・ FOX reagent
・ Fox Reality Awards
・ Fox Reality Channel
・ Fox Report
・ Fox Retro
・ Fox Ridge
・ Fox Ridge State Park
・ Fox River
・ Fox River (Alaska)
・ Fox River (Buller)


Dictionary Lists
翻訳と辞書 辞書検索 [ 開発暫定版 ]
スポンサード リンク

FOX proteins : ウィキペディア英語版
FOX proteins
FOX (Forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Many FOX proteins are important to embryonic development. FOX proteins also have pioneering transcription activity by being able to bind condensed chromatin during cell differentiation processes.
The defining feature of FOX proteins is the ''forkhead box'', a sequence of 80 to 100 amino acids forming a motif that binds to DNA. This forkhead motif is also known as the winged helix due to the butterfly-like appearance of the loops in the protein structure of the domain. Forkhead genes are a subgroup of the helix-turn-helix class of proteins.
==Biological roles==

Many genes encoding FOX proteins have been identified. For example,
the FOXF2 gene encodes ''forkhead box F2'', one of many human homologues of the ''Drosophila melanogaster'' transcription factor forkhead. FOXF2 is expressed in lung and placenta.
Some FOX genes are downstream targets of the hedgehog signaling pathway, which plays a role in the development of basal cell carcinomas.
Members of the class O regulate metabolism, cellular proliferation, stress tolerance and possibly lifespan. The activity of FoxO is controlled by post-translational modifications, including phosphorylation, acetylation and ubiquitination.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「FOX proteins」の詳細全文を読む



スポンサード リンク
翻訳と辞書 : 翻訳のためのインターネットリソース

Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.